BASIC SCIENCE CORE

To combat the tuberculosis (TB) epidemic effectively, we need to reinvigorate TB basic science research with an infusion of new investigators, novel perspectives, and cutting-edge innovations. The goal of the Basic Science Core of the UC TRAC is to address the need to accelerate innovative, multidisciplinary research in tuberculosis research that spans the spectrum of disciplines from basic to clinical research. We expect to catalyze innovation and multidisciplinary work in TB research by: (1) Promoting New Investigators (NIs) in their TB research career by providing specific mentorship and training, and (2) Lowering the barriers to entry for New Investigators and non-TB researchers to bring innovative ideas and technologies to TB research through a set of innovative pilot awards. By providing access to expertise in planning TB experiments and the relevant, trained manpower to execute the experiments, we will have removed probably the biggest barrier for NIs to engage in TB-relevant research. The Basic Science Core expects to have radical benefits in accelerating fundamental discoveries in TB research and provides a fit-for-purpose model of resource access, mentorship and training designed specifically to address the needs of TB basic scientists.

Specific Aims:

• Accelerator Awards designed to lower barriers of entry for new investigators

• Provide a consultation service in basic TB research regarding study design, optimal collaborative partners, analysis, and interpretation

• Mentor new investigators in the conduct of basic TB research